Protein kinase Cθ controls type 2 innate lymphoid cell and TH2 responses to house dust mite allergen
F Madouri, P Chenuet, C Beuraud, L Fauconnier… - Journal of Allergy and …, 2017 - Elsevier
Background Protein kinase C (PKC) θ, a serine/threonine kinase, is involved in TH 2 cell
activation and proliferation. Type 2 innate lymphoid cells (ILC2s) resemble TH 2 cells and
produce the TH 2 cytokines IL-5 and IL-13 but lack antigen-specific receptors. The
mechanism by which PKC-θ drives innate immune cells to instruct TH 2 responses in
patients with allergic lung inflammation remains unknown. Objectives We hypothesized that
PKC-θ contributes to ILC2 activation and might be necessary for ILC2s to instruct the TH 2 …
activation and proliferation. Type 2 innate lymphoid cells (ILC2s) resemble TH 2 cells and
produce the TH 2 cytokines IL-5 and IL-13 but lack antigen-specific receptors. The
mechanism by which PKC-θ drives innate immune cells to instruct TH 2 responses in
patients with allergic lung inflammation remains unknown. Objectives We hypothesized that
PKC-θ contributes to ILC2 activation and might be necessary for ILC2s to instruct the TH 2 …