[HTML][HTML] An airway epithelial iNOS–DUOX2–thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma

N Voraphani, MT Gladwin, AU Contreras… - Mucosal …, 2014 - Elsevier
Severe refractory asthma is associated with enhanced nitrative stress. To determine the
mechanisms for high nitrative stress in human severe asthma (SA), 3-nitrotyrosine (3NT)
was compared with Th1 and Th2 cytokine expression. In SA, high 3NT levels were
associated with high interferon (IFN)-γ and low interleukin (IL)-13 expression, both of which
have been reported to increase inducible nitric oxide synthase (iNOS) in human airway
epithelial cells (HAECs). We found that IL-13 and IFN-γ synergistically enhanced iNOS …