Systematic comparison of drug-tolerant assays for anti-drug antibodies in a cohort of adalimumab-treated rheumatoid arthritis patients
K Bloem, A van Leeuwen, G Verbeek… - Journal of …, 2015 - Elsevier
Drug interference complicates assessment of immunogenicity of biologicals and results in
an underestimation of anti-drug antibody (ADA) formation. Drug-tolerant assays have the
potential to overcome such limitations. However, to which extent drug-tolerant assays
provide an unbiased picture of the antibody response to a biological is unknown. In this
study, we compared the measurement of ADA to adalimumab in 94 consecutive
adalimumab-treated rheumatoid arthritis patients using the traditional antigen binding test …
an underestimation of anti-drug antibody (ADA) formation. Drug-tolerant assays have the
potential to overcome such limitations. However, to which extent drug-tolerant assays
provide an unbiased picture of the antibody response to a biological is unknown. In this
study, we compared the measurement of ADA to adalimumab in 94 consecutive
adalimumab-treated rheumatoid arthritis patients using the traditional antigen binding test …
