Extended analysis identifies drug-specific association of 2 distinct HLA class II haplotypes for development of immunogenicity to adalimumab and infliximab
RDP Doherty, H Liao, JJ Satsangi, N Ternette - Gastroenterology, 2020 - gastrojournal.org
Results Pearson correlation analysis indicates weak correlation among the 3 HLA-DQA1∗
05 protein variants (HLA-DQA1∗ 05: 01 vs HLA-DQA1∗ 05: 03 ρ=− 0.0219; HLA-DQA1∗
05: 01 vs HLA-DQA1∗ 05: 05 ρ=− 0.0921; HLA-DQA1∗ 05: 03 vs HLA-DQA1∗ 05: 05 ρ=−
0.0196), indicating these variants are biologically unrelated and should be considered
separately. Analysis on HLA-DQA1∗ 05: 03 was not progressed, as it exists in only 1
individual in the PANTS cohort.
05 protein variants (HLA-DQA1∗ 05: 01 vs HLA-DQA1∗ 05: 03 ρ=− 0.0219; HLA-DQA1∗
05: 01 vs HLA-DQA1∗ 05: 05 ρ=− 0.0921; HLA-DQA1∗ 05: 03 vs HLA-DQA1∗ 05: 05 ρ=−
0.0196), indicating these variants are biologically unrelated and should be considered
separately. Analysis on HLA-DQA1∗ 05: 03 was not progressed, as it exists in only 1
individual in the PANTS cohort.