Development of antidrug antibodies against adalimumab and association with disease activity and treatment failure during long-term follow-up
GM Bartelds, CLM Krieckaert, MT Nurmohamed… - Jama, 2011 - jamanetwork.com
Context Short-term data on the immunogenicity of monoclonal antibodies showed
associations between the development of antidrug antibodies and diminished serum drug
levels, and a diminished treatment response. Little is known about the clinical relevance of
antidrug antibodies against these drugs during long-term follow-up. Objective To examine
the course of antidrug antibody formation against fully human monoclonal antibody
adalimumab and its clinical relevance during long-term (3-year) follow-up of patients with …
associations between the development of antidrug antibodies and diminished serum drug
levels, and a diminished treatment response. Little is known about the clinical relevance of
antidrug antibodies against these drugs during long-term follow-up. Objective To examine
the course of antidrug antibody formation against fully human monoclonal antibody
adalimumab and its clinical relevance during long-term (3-year) follow-up of patients with …
