Effect of moderate aerobic exercise training on endothelial function and arterial stiffness in CKD stages 3-4: a randomized controlled trial
AH Van Craenenbroeck… - American Journal of …, 2015 - Elsevier
AH Van Craenenbroeck, EM Van Craenenbroeck, K Van Ackeren, CJ Vrints, VM Conraads…
American Journal of Kidney Diseases, 2015•ElsevierBackground Evidence of a beneficial effect of exercise training on mediators of vascular
disease is accumulating in chronic kidney disease (CKD), but its effect on vascular function
in vivo still has to be established. The present study was designed to investigate whether a
formal aerobic exercise training program improves peripheral endothelial function in
patients with CKD stages 3 to 4. Study Design Randomized controlled trial with a parallel-
group design. Setting & Participants 48 patients with CKD stages 3 to 4 without established …
disease is accumulating in chronic kidney disease (CKD), but its effect on vascular function
in vivo still has to be established. The present study was designed to investigate whether a
formal aerobic exercise training program improves peripheral endothelial function in
patients with CKD stages 3 to 4. Study Design Randomized controlled trial with a parallel-
group design. Setting & Participants 48 patients with CKD stages 3 to 4 without established …
Background
Evidence of a beneficial effect of exercise training on mediators of vascular disease is accumulating in chronic kidney disease (CKD), but its effect on vascular function in vivo still has to be established. The present study was designed to investigate whether a formal aerobic exercise training program improves peripheral endothelial function in patients with CKD stages 3 to 4.
Study Design
Randomized controlled trial with a parallel-group design.
Setting & Participants
48 patients with CKD stages 3 to 4 without established cardiovascular disease were randomly assigned to either an exercise training program or usual care. 40 patients completed the study (exercise training, 19; usual care, 21).
Intervention
The 3-month home-based aerobic training program consisted of 4 daily cycling sessions of 10 minutes each at a target heart rate, calculated as 90% of the heart rate achieved at the anaerobic threshold. Patients in the usual-care group were given standard therapy.
Outcomes
The primary outcome was peripheral endothelial function. Secondary outcomes were aerobic capacity, arterial stiffness, numbers of endothelial (EPCs) and osteogenic progenitor cells (OPCs), migratory function of circulatory angiogenic cells, and health-related quality of life.
Measurements
Endothelial function was assessed with flow-mediated dilation of the brachial artery, aerobic capacity by peak oxygen uptake (Vo2peak), arterial stiffness by carotid-femoral pulse wave velocity, numbers of EPCs and OPCs by flow cytometry, circulatory angiogenic cell function by an in vitro migratory assay, and quality of life by the Kidney Disease Quality of Life−Short Form questionnaire.
Results
Exercise training significantly improved Vo2peak and quality of life, but not in vivo vascular function (flow-mediated dilation and carotid-femoral pulse wave velocity) or cellular markers for vascular function (EPC and OPC count and circulatory angiogenic cell migratory function).
Limitations
Short duration and intermittent nature of the exercise intervention.
Conclusions
In patients with CKD stages 3 to 4 without overt cardiovascular disease, 3 months of aerobic exercise training improved Vo2peak and quality of life, without altering endothelial function or arterial stiffness.
Elsevier
