[HTML][HTML] Functional evaluation of TNFAIP3 (A20) in rheumatoid arthritis
LM Elsby, G Orozco, J Denton… - Clinical and …, 2010 - ncbi.nlm.nih.gov
Clinical and experimental rheumatology, 2010•ncbi.nlm.nih.gov
Objectives To determine the protein expression of TNFAIP3 in synovium and to show the
capability of 6q23 intergenic SNPs, associated with rheumatoid arthritis (RA) susceptibility,
to influence TNFAIP3 gene transcription. Methods Immunohistochemistry for TNFAIP3, NF-
κB p65 and phosphorylated NF-κB p65 protein expression was performed in 6 RA knee joint
synovium samples compared to 9 osteoarthritis (OA) samples.
capability of 6q23 intergenic SNPs, associated with rheumatoid arthritis (RA) susceptibility,
to influence TNFAIP3 gene transcription. Methods Immunohistochemistry for TNFAIP3, NF-
κB p65 and phosphorylated NF-κB p65 protein expression was performed in 6 RA knee joint
synovium samples compared to 9 osteoarthritis (OA) samples.
Abstract
Objectives
To determine the protein expression of TNFAIP3 in synovium and to show the capability of 6q23 intergenic SNPs, associated with rheumatoid arthritis (RA) susceptibility, to influence TNFAIP3 gene transcription.
Methods
Immunohistochemistry for TNFAIP3, NF-κB p65 and phosphorylated NF-κB p65 protein expression was performed in 6 RA knee joint synovium samples compared to 9 osteoarthritis (OA) samples.
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