Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity

DW Vaughn, S Green, S Kalayanarooj… - The Journal of …, 2000 - academic.oup.com
DW Vaughn, S Green, S Kalayanarooj, BL Innis, S Nimmannitya, S Suntayakorn, TP Endy…
The Journal of infectious diseases, 2000academic.oup.com
Viremia titers in serial plasma samples from 168 children with acute dengue virus infection
who were enrolled in a prospective study at 2 hospitals in Thailand were examined to
determine the role of virus load in the pathogenesis of dengue hemorrhagic fever (DHF).
The infecting virus serotype was identified for 165 patients (DEN-1, 46 patients; DEN-2, 47
patients; DEN-3, 47 patients, DEN-4, 25 patients). Patients with DEN-2 infections
experienced more severe disease than those infected with other serotypes. Eighty-one …
Abstract
Viremia titers in serial plasma samples from 168 children with acute dengue virus infection who were enrolled in a prospective study at 2 hospitals in Thailand were examined to determine the role of virus load in the pathogenesis of dengue hemorrhagic fever (DHF). The infecting virus serotype was identified for 165 patients (DEN-1, 46 patients; DEN-2, 47 patients; DEN-3, 47 patients, DEN-4, 25 patients). Patients with DEN-2 infections experienced more severe disease than those infected with other serotypes. Eighty-one percent of patients experienced a secondary dengue virus infection that was associated with more severe disease. Viremia titers were determined for 41 DEN-1 and 46 DEN-2 patients. Higher peak titers were associated with increased disease severity for the 31 patients with a peak titer identified (mean titer of 107.6 for those with dengue fever vs. 108.5 for patients with DHF, P = .01). Increased dengue disease severity correlated with high viremia titer, secondary dengue virus infection, and DEN-2 virus type.
Oxford University Press