Expression of bone morphogenetic proteins in acute promyelocytic leukemia before and after combined all trans-retinoic acid and cytotoxic treatment
We investigated the dynamics of bone morphogenetic protein (BMP) and their receptor
mRNA expression in relation to combined treatment with all trans-retinoic acid (ATRA) and
chemotherapy in four patients with acute promyelocytic leukemia (APL). Reverse
transcription–polymerase chain reaction (RT–PCR) analysis of the bone marrow cells at
diagnosis showed strong expression of BMP-2,-4, and-7, and their receptors RIA, RIB, and
RII, parallel to the expression of promyelocytic leukemia/retinoic acid receptor α …
mRNA expression in relation to combined treatment with all trans-retinoic acid (ATRA) and
chemotherapy in four patients with acute promyelocytic leukemia (APL). Reverse
transcription–polymerase chain reaction (RT–PCR) analysis of the bone marrow cells at
diagnosis showed strong expression of BMP-2,-4, and-7, and their receptors RIA, RIB, and
RII, parallel to the expression of promyelocytic leukemia/retinoic acid receptor α …