[HTML][HTML] Phosphatase of Regenerating Liver 2 (PRL2) Is Essential for Placental Development by Down-regulating PTEN (Phosphatase and Tensin Homologue …
The PRL (phosphatase of regenerating liver) phosphatases are implicated in the control of
cell proliferation and invasion. Aberrant PRL expression is associated with progression and
metastasis of multiple cancers. However, the specific in vivo function of the PRLs remains
elusive. Here we show that deletion of PRL2, the most ubiquitously expressed PRL family
member, leads to impaired placental development and retarded growth at both embryonic
and adult stages. Ablation of PRL2 inactivates Akt and blocks glycogen cell proliferation …
cell proliferation and invasion. Aberrant PRL expression is associated with progression and
metastasis of multiple cancers. However, the specific in vivo function of the PRLs remains
elusive. Here we show that deletion of PRL2, the most ubiquitously expressed PRL family
member, leads to impaired placental development and retarded growth at both embryonic
and adult stages. Ablation of PRL2 inactivates Akt and blocks glycogen cell proliferation …