[HTML][HTML] Transcriptional activation of transforming growth factor β1 and its receptors by the Kruppel-like factor Zf9/core promoter-binding protein and Sp1: potential …
Y Kim, V Ratziu, SG Choi, A Lalazar, G Theiss… - Journal of Biological …, 1998 - ASBMB
We have explored the regulation of transforming growth factor β (TGF-β) activity in tissue
repair by examining the interactions of Zf9/core promoter-binding protein, a Kruppel-like zinc
finger transcription factor induced early in hepatic stellate cell (HSC) activation, with
promoters for TGF-β1 and TGF-β receptors, types I and II. Nuclear extracts from culture-
activated HSCs bound avidly by electrophoretic mobility shift assay to two tandem GC boxes
within the TGF-β1 promoter but minimally to a single GC box; these results correlated with …
repair by examining the interactions of Zf9/core promoter-binding protein, a Kruppel-like zinc
finger transcription factor induced early in hepatic stellate cell (HSC) activation, with
promoters for TGF-β1 and TGF-β receptors, types I and II. Nuclear extracts from culture-
activated HSCs bound avidly by electrophoretic mobility shift assay to two tandem GC boxes
within the TGF-β1 promoter but minimally to a single GC box; these results correlated with …