Functional peptide of dermatopontin produces fibrinogen fibrils and modifies its biological activity
W Wu, O Okamoto, A Kato, N Matsuo, J Kumai… - Journal of …, 2014 - Elsevier
Background Dermatopontin (DP), a small extracellular matrix protein, interacts with both
fibrinogen and fibrin. DP accelerates fibrin fibril formation and enhances cell adhesion to
fibrin fibrils but DP does not influence fibrinogen fibril formation. We have previously
demonstrated that DP-4 (PHGQVVVAVRS) is a functional dermatopontin peptide (Wu et al.,
2014). Objective Identification of biological functions of DP-4. Methods Protein–protein
interactions were examined by solid-phase assay. The kinetics of fibrinogen/fibrin polymer …
fibrinogen and fibrin. DP accelerates fibrin fibril formation and enhances cell adhesion to
fibrin fibrils but DP does not influence fibrinogen fibril formation. We have previously
demonstrated that DP-4 (PHGQVVVAVRS) is a functional dermatopontin peptide (Wu et al.,
2014). Objective Identification of biological functions of DP-4. Methods Protein–protein
interactions were examined by solid-phase assay. The kinetics of fibrinogen/fibrin polymer …