Deuterium nuclear magnetic resonance spin-imaging of D2O: A potential exogenous MRI label
CS Ewy, EE Babcock, JJH Ackerman - Magnetic Resonance Imaging, 1986 - Elsevier
Recent development of high-field wide-bore magnets for spin-imaging applications has
made feasible the observation of nuclear spins of low sensitivity. We propose the in vivo use
of deuterium, specifically D 2 O, as an exogeneous magnetic resonance nuclear spin label
of clinically significant potential. The combination of an efficient quadrupole relaxation
mechanism, low acute toxicity and ready commercial availability of D 2 O for in situ
enrichment will provide sufficient sensitivity for magnetic resonance imaging.
made feasible the observation of nuclear spins of low sensitivity. We propose the in vivo use
of deuterium, specifically D 2 O, as an exogeneous magnetic resonance nuclear spin label
of clinically significant potential. The combination of an efficient quadrupole relaxation
mechanism, low acute toxicity and ready commercial availability of D 2 O for in situ
enrichment will provide sufficient sensitivity for magnetic resonance imaging.
