Genetics of type 1 diabetes
MJ Redondo, AK Steck, A Pugliese - Pediatric diabetes, 2018 - Wiley Online Library
MJ Redondo, AK Steck, A Pugliese
Pediatric diabetes, 2018•Wiley Online LibraryType 1 diabetes (T1D) results from immune‐mediated loss of pancreatic beta cells leading
to insulin deficiency. It is the most common form of diabetes in children, and its incidence is
on the rise. This article reviews the current knowledge on the genetics of T1D. In particular,
we discuss the influence of HLA and non‐HLA genes on T1D risk and disease progression
through the preclinical stages of the disease, and the development of genetic scores that
can be applied to disease prediction. Racial/ethnic differences, challenges and future …
to insulin deficiency. It is the most common form of diabetes in children, and its incidence is
on the rise. This article reviews the current knowledge on the genetics of T1D. In particular,
we discuss the influence of HLA and non‐HLA genes on T1D risk and disease progression
through the preclinical stages of the disease, and the development of genetic scores that
can be applied to disease prediction. Racial/ethnic differences, challenges and future …
Type 1 diabetes (T1D) results from immune‐mediated loss of pancreatic beta cells leading to insulin deficiency. It is the most common form of diabetes in children, and its incidence is on the rise. This article reviews the current knowledge on the genetics of T1D. In particular, we discuss the influence of HLA and non‐HLA genes on T1D risk and disease progression through the preclinical stages of the disease, and the development of genetic scores that can be applied to disease prediction. Racial/ethnic differences, challenges and future directions in the genetics of T1D are also discussed.
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