Global characterization of protein secretion from human macrophages following non-canonical caspase-4/5 inflammasome activation
MB Lorey, K Rossi, KK Eklund, TA Nyman… - Molecular & Cellular …, 2017 - ASBMB
Gram-negative bacteria are associated with a wide spectrum of infectious diseases in
humans. Inflammasomes are cytosolic protein complexes that are assembled when the cell
encounters pathogens or other harmful agents. The non-canonical caspase-4/5
inflammasome is activated by Gram-negative bacteria-derived lipopolysaccharide (LPS) and
by endogenous oxidized phospholipids. Protein secretion is a critical component of the
innate immune response. Here, we have used label-free quantitative proteomics to …
humans. Inflammasomes are cytosolic protein complexes that are assembled when the cell
encounters pathogens or other harmful agents. The non-canonical caspase-4/5
inflammasome is activated by Gram-negative bacteria-derived lipopolysaccharide (LPS) and
by endogenous oxidized phospholipids. Protein secretion is a critical component of the
innate immune response. Here, we have used label-free quantitative proteomics to …
