Single-cell transcriptome profiling of the kidney glomerulus identifies key cell types and reactions to injury
JJ Chung, L Goldstein, YJJ Chen, J Lee… - Journal of the …, 2020 - journals.lww.com
Background The glomerulus is a specialized capillary bed that is involved in urine
production and BP control. Glomerular injury is a major cause of CKD, which is epidemic
and without therapeutic options. Single-cell transcriptomics has radically improved our
ability to characterize complex organs, such as the kidney. Cells of the glomerulus, however,
have been largely underrepresented in previous single-cell kidney studies due to their
paucity and intractability. Methods Single-cell RNA sequencing comprehensively …
production and BP control. Glomerular injury is a major cause of CKD, which is epidemic
and without therapeutic options. Single-cell transcriptomics has radically improved our
ability to characterize complex organs, such as the kidney. Cells of the glomerulus, however,
have been largely underrepresented in previous single-cell kidney studies due to their
paucity and intractability. Methods Single-cell RNA sequencing comprehensively …
