[HTML][HTML] MicroRNA-155 deficiency leads to decreased atherosclerosis, increased white adipose tissue obesity, and non-alcoholic fatty liver disease: a novel mouse …
Obesity paradox (OP) describes a widely observed clinical finding of improved
cardiovascular fitness and survival in some overweight or obese patients. The molecular
mechanisms underlying OP remain enigmatic partly due to a lack of animal models mirroring
OP in patients. Using apolipoprotein E knock-out (apoE−/−) mice on a high fat (HF) diet as
an atherosclerotic obesity model, we demonstrated 1) microRNA-155 (miRNA-155, miR-
155) is significantly up-regulated in the aortas of apoE−/− mice, and miR-155 deficiency in …
cardiovascular fitness and survival in some overweight or obese patients. The molecular
mechanisms underlying OP remain enigmatic partly due to a lack of animal models mirroring
OP in patients. Using apolipoprotein E knock-out (apoE−/−) mice on a high fat (HF) diet as
an atherosclerotic obesity model, we demonstrated 1) microRNA-155 (miRNA-155, miR-
155) is significantly up-regulated in the aortas of apoE−/− mice, and miR-155 deficiency in …
