[HTML][HTML] Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo
S Bekkering, I van den Munckhof, T Nielen, E Lamfers… - Atherosclerosis, 2016 - Elsevier
Background and aims We have recently reported that monocytes can undergo functional
and transcriptional reprogramming towards a long-term pro-inflammatory phenotype after
brief in vitro exposure to atherogenic stimuli such as oxidized LDL. This process is termed
'trained immunity', and is mediated by epigenetic remodeling and a metabolic switch
towards increased aerobic glycolysis. We hypothesize that trained immunity contributes to
atherogenesis. Therefore, we investigated the inflammatory phenotype and epigenetic …
and transcriptional reprogramming towards a long-term pro-inflammatory phenotype after
brief in vitro exposure to atherogenic stimuli such as oxidized LDL. This process is termed
'trained immunity', and is mediated by epigenetic remodeling and a metabolic switch
towards increased aerobic glycolysis. We hypothesize that trained immunity contributes to
atherogenesis. Therefore, we investigated the inflammatory phenotype and epigenetic …
