Anti-CD20 treatment depletes B-cells in blood and lymphatic tissue of cynomolgus monkeys
C Schröder, AM Azimzadeh, G Wu, JO Price… - Transplant …, 2003 - Elsevier
Introduction: Macaque species offer a valuable model for translational allo-transplantation
and tolerance studies. Cardiac allograft vasculopathy in Macaca fascicularis is associated
with elaboration of anti-donor antibodies. Since T-independent pathways of B cell activation
have been described, and anti-B cell strategies have proven to be a fruitful tolerogenic
adjunct in rodent and xenogenic models, here we investigate whether an anti-CD20
antibody (rituximab) would be useful to deplete B-cells in a pre-clinical allo-transplantation …
and tolerance studies. Cardiac allograft vasculopathy in Macaca fascicularis is associated
with elaboration of anti-donor antibodies. Since T-independent pathways of B cell activation
have been described, and anti-B cell strategies have proven to be a fruitful tolerogenic
adjunct in rodent and xenogenic models, here we investigate whether an anti-CD20
antibody (rituximab) would be useful to deplete B-cells in a pre-clinical allo-transplantation …