A chromosomal duplication encompassing interleukin-33 causes a novel hyper IgE phenotype characterized by eosinophilic esophagitis and generalized …
Interleukin (IL)-33 is a member of the IL-1 cytokine family and is secreted by fibroblasts,
endothelial cells, and epithelial cells in tissues (lung, skin, and gastrointestinal) that are
exposed to the environment. 1 IL-33 is stored in the nucleus and environmental allergens
trigger RIPK1-caspase 8 ripoptosome activation in epithelial cells to enable IL-33 maturation
and release. 2 IL-33 signals via its receptor ST2, which is found on multiple immune cells,
such as eosinophils, mast cells, T cells, macrophages, basophils, and type 2 innate …
endothelial cells, and epithelial cells in tissues (lung, skin, and gastrointestinal) that are
exposed to the environment. 1 IL-33 is stored in the nucleus and environmental allergens
trigger RIPK1-caspase 8 ripoptosome activation in epithelial cells to enable IL-33 maturation
and release. 2 IL-33 signals via its receptor ST2, which is found on multiple immune cells,
such as eosinophils, mast cells, T cells, macrophages, basophils, and type 2 innate …
