Jakinibs for the treatment of immune dysregulation in patients with gain-of-function signal transducer and activator of transcription 1 (STAT1) or STAT3 mutations
STAT1 and STAT3 belong to a 7-member family of transcription factors that help transmit key
cytokine signals from cell membrane receptors to the nucleus by using Janus kinases
(JAKs). Classically, after a cytokine binds to its receptor, one of 4 JAKs is activated and
phosphorylates the cytokine receptor. STAT molecules are then recruited to the activated
receptor, are phosphorylated, dimerize, and translocate to the nucleus, where they alter
gene expression. Activation of STAT1 and STAT3 occurs downstream of numerous …
cytokine signals from cell membrane receptors to the nucleus by using Janus kinases
(JAKs). Classically, after a cytokine binds to its receptor, one of 4 JAKs is activated and
phosphorylates the cytokine receptor. STAT molecules are then recruited to the activated
receptor, are phosphorylated, dimerize, and translocate to the nucleus, where they alter
gene expression. Activation of STAT1 and STAT3 occurs downstream of numerous …
