Redefining precision medicine in disorders of immune dysregulation
JW Leiding, M Ballow - The Journal of Allergy and Clinical …, 2019 - jaci-inpractice.org
Primary antibody immune deficiencies account for more than 50% of the primary
immunodeficiency diseases. Of these, common variable immune deficiency (CVID) makes
up most of these patients. CVID is a very heterogeneous disease with a broad spectrum of
immune abnormalities including at one end of the spectrum, low B cells, T-cell lymphopenia,
and immune dysregulation with abnormalities in regulatory T (Treg) cells. 1 The clinical
phenotypes of the latter patients with CVID commonly include autoimmunity, and …
immunodeficiency diseases. Of these, common variable immune deficiency (CVID) makes
up most of these patients. CVID is a very heterogeneous disease with a broad spectrum of
immune abnormalities including at one end of the spectrum, low B cells, T-cell lymphopenia,
and immune dysregulation with abnormalities in regulatory T (Treg) cells. 1 The clinical
phenotypes of the latter patients with CVID commonly include autoimmunity, and …