Zebrafish mast cells possess an FcɛRI-like receptor and participate in innate and adaptive immune responses
S Da'as, EM Teh, JT Dobson, GK Nasrallah… - Developmental & …, 2011 - Elsevier
We previously identified a zebrafish mast cell (MC) lineage and now aim to determine if
these cells function analogously in innate and adaptive immunity like their mammalian
counterparts. Intraperitoneal (IP) injection of compound 48/80 or live Aeromonas
salmonicida resulted in significant MC degranulation evident histologically and by increased
plasma tryptase compared with saline-injected controls (p= 0.0006, 0.005, respectively). Pre-
treatment with ketotifen abrogated these responses (p= 0.0004, 0.005, respectively). Cross …
these cells function analogously in innate and adaptive immunity like their mammalian
counterparts. Intraperitoneal (IP) injection of compound 48/80 or live Aeromonas
salmonicida resulted in significant MC degranulation evident histologically and by increased
plasma tryptase compared with saline-injected controls (p= 0.0006, 0.005, respectively). Pre-
treatment with ketotifen abrogated these responses (p= 0.0004, 0.005, respectively). Cross …