Aberrant B-cell homeostasis in chronic GVHD
S Sarantopoulos, J Ritz - Blood, The Journal of the American …, 2015 - ashpublications.org
Blood, The Journal of the American Society of Hematology, 2015•ashpublications.org
Recent studies have compelled further interest in the potential pathological role of B cells in
chronic graft-versus-host disease (cGVHD). In patients with cGVHD, B cells are activated
and primed for survival via B-cell activating factor and B-cell receptor–associated pathways.
Understanding the signaling pathways that drive immune pathology in cGVHD will facilitate
the development of new strategies to selectively target aberrantly activated B cells and
restore normal B-cell homeostasis after allogeneic stem cell transplantation.
chronic graft-versus-host disease (cGVHD). In patients with cGVHD, B cells are activated
and primed for survival via B-cell activating factor and B-cell receptor–associated pathways.
Understanding the signaling pathways that drive immune pathology in cGVHD will facilitate
the development of new strategies to selectively target aberrantly activated B cells and
restore normal B-cell homeostasis after allogeneic stem cell transplantation.
Abstract
Recent studies have compelled further interest in the potential pathological role of B cells in chronic graft-versus-host disease (cGVHD). In patients with cGVHD, B cells are activated and primed for survival via B-cell activating factor and B-cell receptor–associated pathways. Understanding the signaling pathways that drive immune pathology in cGVHD will facilitate the development of new strategies to selectively target aberrantly activated B cells and restore normal B-cell homeostasis after allogeneic stem cell transplantation.
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