[HTML][HTML] Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype

K Ohashi, JL Parker, N Ouchi, A Higuchi, JA Vita… - Journal of Biological …, 2010 - ASBMB
It is established that the adipocyte-derived cytokine adiponectin protects against
cardiovascular and metabolic diseases, but the effect of this adipokine on macrophage
polarization, an important mediator of disease progression, has never been assessed. We
hypothesized that adiponectin modulates macrophage polarization from that resembling a
classically activated M1 phenotype to that resembling alternatively-activated M2 cells.
Peritoneal macrophages and the stromal vascular fraction (SVF) cells of adipose tissue …