The Duffy antigen receptor for chemokines in acute renal failure: A facilitator of renal chemokine presentation
A Zarbock, M Schmolke, SG Bockhorn… - Critical care …, 2007 - journals.lww.com
Objective: Acute renal failure remains a major challenge in critical care medicine. Both
neutrophils and chemokines have been proposed as key components in the development of
acute renal failure. Although the Duffy antigen receptor for chemokines (DARC) is present in
several tissues and a highly specific ligand for various chemokines, its exact role in vivo
remains unclear. Design: Prospective, controlled experimental study. Setting: University-
based research laboratory. Subjects: C57BL/6 wild-type and DARC gene-deficient mice …
neutrophils and chemokines have been proposed as key components in the development of
acute renal failure. Although the Duffy antigen receptor for chemokines (DARC) is present in
several tissues and a highly specific ligand for various chemokines, its exact role in vivo
remains unclear. Design: Prospective, controlled experimental study. Setting: University-
based research laboratory. Subjects: C57BL/6 wild-type and DARC gene-deficient mice …