[HTML][HTML] Intestinal tuft cells: epithelial sentinels linking luminal cues to the immune system
F Gerbe, P Jay - Mucosal immunology, 2016 - Elsevier
Epithelial tuft cells (also known as “brush” cells in the airway) were first identified
morphologically, almost six decades ago in the trachea and gastro-intestinal tract, but their
function remained mysterious until three almost simultaneous reports recently revealed their
essential role in the initiation of immune type 2 responses. This is a new and exciting
example of cooperation between the epithelial and haematopoietic compartments for the
management of enteric parasite infections. Here we review tuft cell functions and markers …
morphologically, almost six decades ago in the trachea and gastro-intestinal tract, but their
function remained mysterious until three almost simultaneous reports recently revealed their
essential role in the initiation of immune type 2 responses. This is a new and exciting
example of cooperation between the epithelial and haematopoietic compartments for the
management of enteric parasite infections. Here we review tuft cell functions and markers …