[HTML][HTML] Targeted disruption of Ig-Hepta/Gpr116 causes emphysema-like symptoms that are associated with alveolar macrophage activation
DM Ariestanti, H Ando, S Hirose… - Journal of biological …, 2015 - ASBMB
Ig-Hepta/GPR116 is a member of the G protein-coupled receptor family predominantly
expressed in the alveolar type II epithelial cells of the lung. Previous studies have shown
that Ig-Hepta is essential for lung surfactant homeostasis, and loss of its function results in
high accumulation of surfactant lipids and proteins in the alveolar space. Ig-Hepta knock-out
(Ig-Hepta−/−) mice also exhibit emphysema-like symptoms, including accumulation of foamy
alveolar macrophages (AMs), but its pathogenic mechanism is unknown. Here, we show that …
expressed in the alveolar type II epithelial cells of the lung. Previous studies have shown
that Ig-Hepta is essential for lung surfactant homeostasis, and loss of its function results in
high accumulation of surfactant lipids and proteins in the alveolar space. Ig-Hepta knock-out
(Ig-Hepta−/−) mice also exhibit emphysema-like symptoms, including accumulation of foamy
alveolar macrophages (AMs), but its pathogenic mechanism is unknown. Here, we show that …