A novel member of the G protein-coupled receptor (GPCR) family was cloned and
characterized, which is unique, among the members, in its long extracellular domain
comprising Ig-like repeats and in its high expression predominantly in the lung. The clone (Ig-
Hepta) was first identified as a polymerase chain reaction product generated with primers
designed to amplify secretin receptor family members including the parathyroid hormone-
related peptide receptors. Analysis of the open reading frame of cDNAs isolated from a rat …