Purinoceptor agonists stimulate phosphatidylcholine secretion in primary cultures of adult rat type II pneumocytes
AM Gilfillan, SA Rooney - Biochimica et Biophysica Acta (BBA)-Lipids and …, 1987 - Elsevier
We examined the effect of purinoceptor agonists on phosphatidylcholine secretion in
primary cultures of type II pneumocytes from adult rats. Surfactant is a major product of the
type II cell and phosphatidylcholine is its principal component. Adenosine, AMP, ADP and
ATP stimulated phosphatidylcholine secretion in a concentration-dependent manner. At the
optimum concentration (1 mM), adenosine and AMP stimulated phosphatidylcholine
secretion more than 2-fold, while ATP stimulated 5-fold and ADP almost 7-fold. Because of …
primary cultures of type II pneumocytes from adult rats. Surfactant is a major product of the
type II cell and phosphatidylcholine is its principal component. Adenosine, AMP, ADP and
ATP stimulated phosphatidylcholine secretion in a concentration-dependent manner. At the
optimum concentration (1 mM), adenosine and AMP stimulated phosphatidylcholine
secretion more than 2-fold, while ATP stimulated 5-fold and ADP almost 7-fold. Because of …