Single-cell RNA sequencing of urinary cells reveals distinct cellular diversity in COVID-19–associated AKI
MD Cheung, EN Erman, S Liu, NB Erdmann… - Kidney360, 2022 - journals.lww.com
Background AKI is a common sequela of infection with SARS-CoV-2 and contributes to the
severity and mortality from COVID-19. Here, we tested the hypothesis that kidney alterations
induced by COVID-19–associated AKI could be detected in cells collected from urine.
Methods We performed single-cell RNA sequencing (scRNAseq) on cells recovered from
the urine of eight hospitalized patients with COVID-19 with (n= 5) or without AKI (n= 3) as
well as four patients with non–COVID-19 AKI (n= 4) to assess differences in cellular …
severity and mortality from COVID-19. Here, we tested the hypothesis that kidney alterations
induced by COVID-19–associated AKI could be detected in cells collected from urine.
Methods We performed single-cell RNA sequencing (scRNAseq) on cells recovered from
the urine of eight hospitalized patients with COVID-19 with (n= 5) or without AKI (n= 3) as
well as four patients with non–COVID-19 AKI (n= 4) to assess differences in cellular …
