Glucagon-like peptide-1 receptor regulation of basal dopamine transporter activity is species-dependent
ME Jensen, A Galli, M Thomsen, KL Jensen… - Neurochemistry …, 2020 - Elsevier
Introduction A solid body of preclinical evidence shows that glucagon-like peptide-1 receptor
(GLP-1R) agonists attenuate the effects of substance use disorder related behaviors. The
mechanisms underlying these effects remain elusive. In the present study, we hypothesized
that GLP-1R activation modulates dopaminetransporter (DAT) and thus dopamine (DA)
homeostasis in striatum. This was evaluated in three different experiments: two preclinical
and one clinical. Methods Rat striatal DA uptake, DA clearance and DAT cell surface …
(GLP-1R) agonists attenuate the effects of substance use disorder related behaviors. The
mechanisms underlying these effects remain elusive. In the present study, we hypothesized
that GLP-1R activation modulates dopaminetransporter (DAT) and thus dopamine (DA)
homeostasis in striatum. This was evaluated in three different experiments: two preclinical
and one clinical. Methods Rat striatal DA uptake, DA clearance and DAT cell surface …
