Defective chemoattractant-induced calcium signalling in S100A9 null neutrophils
The S100 family member S100A9 and its heterodimeric partner, S100A8, are cytosolic Ca2+
binding proteins abundantly expressed in neutrophils. To understand the role of this EF-
hand-containing complex in Ca2+ signalling, neutrophils from S100A9 null mice were
investigated. There was no role for the complex in buffering acute cytosolic Ca2+ elevations.
However, Ca2+ responses to inflammatory agents such as chemokines MIP-2 and KC and
other agonists are altered. For S100A9 null neutrophils, signalling at the level of G proteins …
binding proteins abundantly expressed in neutrophils. To understand the role of this EF-
hand-containing complex in Ca2+ signalling, neutrophils from S100A9 null mice were
investigated. There was no role for the complex in buffering acute cytosolic Ca2+ elevations.
However, Ca2+ responses to inflammatory agents such as chemokines MIP-2 and KC and
other agonists are altered. For S100A9 null neutrophils, signalling at the level of G proteins …