[HTML][HTML] IL-17-mediated antifungal defense in the oral mucosa is independent of neutrophils

K Trautwein-Weidner, A Gladiator, S Nur, P Diethelm… - Mucosal …, 2015 - Elsevier
Abstract Interleukin-17 (IL-17)-mediated immunity has emerged as a crucial host defense
mechanism against Candida albicans infections in mucosal tissues and the skin. The
precise mechanism by which the IL-17 pathway prevents fungal outgrowth has not been
clarified. Neutrophils are critical for limiting fungal dissemination and IL-17 is generally
thought to act by regulating neutrophil mobilization and trafficking to the site of infection.
Using a mouse model of oropharyngeal candidiasis (OPC), we found that strikingly the IL-17 …