Mechanisms of human smooth muscle cell proliferation and transplant vasculopathy induced by HLA class I antibodies: in vitro and in vivo studies
M Trayssac, A Nègre-Salvayre, M Thomsen - Human Immunology, 2012 - Elsevier
Vascular smooth muscle cells (SMC) play an important role in the pathophysiology of
transplant vasculopathy (TV), a major cause of late death in patients receiving an organ
transplant. In this review we describe the proliferative effect in vitro and in vivo of HLA class I
antibodies on human SMC. We have developed an experimental model using segments of
human mesenteric arteries transplanted in the position of the infrarenal aorta in
immunodeficient mice (SCID/beige). Weekly injections of transplanted mice with a …
transplant vasculopathy (TV), a major cause of late death in patients receiving an organ
transplant. In this review we describe the proliferative effect in vitro and in vivo of HLA class I
antibodies on human SMC. We have developed an experimental model using segments of
human mesenteric arteries transplanted in the position of the infrarenal aorta in
immunodeficient mice (SCID/beige). Weekly injections of transplanted mice with a …