Molecular MRI of collagen to diagnose and stage liver fibrosis

BC Fuchs, H Wang, Y Yang, L Wei, M Polasek… - Journal of …, 2013 - Elsevier
Background & Aims The gold standard in assessing liver fibrosis is biopsy despite limitations
like invasiveness and sampling error and complications including morbidity and mortality.
Therefore, there is a major unmet medical need to quantify fibrosis non-invasively to
facilitate early diagnosis of chronic liver disease and provide a means to monitor disease
progression. The goal of this study was to evaluate the ability of several magnetic resonance
imaging (MRI) techniques to stage liver fibrosis. Methods A gadolinium (Gd)-based MRI …