Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial
VM Ranieri, PM Suter, C Tortorella, R De Tullio… - Jama, 1999 - jamanetwork.com
ContextStudies have shown that an inflammatory response may be elicited by mechanical
ventilation used for recruitment or derecruitment of collapsed lung units or to overdistend
alveolar regions, and that a lung-protective strategy may reduce this response. ObjectiveTo
test the hypothesis that mechanical ventilation induces a pulmonary and systemic cytokine
response that can be minimized by limiting recruitment or derecruitment and overdistention.
Design and SettingRandomized controlled trial in the intensive care units of 2 European …
ventilation used for recruitment or derecruitment of collapsed lung units or to overdistend
alveolar regions, and that a lung-protective strategy may reduce this response. ObjectiveTo
test the hypothesis that mechanical ventilation induces a pulmonary and systemic cytokine
response that can be minimized by limiting recruitment or derecruitment and overdistention.
Design and SettingRandomized controlled trial in the intensive care units of 2 European …