Lack of phosphoinositide 3-kinase-γ attenuates ventilator-induced lung injury
V Lionetti, A Lisi, E Patrucco, P De Giuli… - Critical care …, 2006 - journals.lww.com
Objective: G protein-coupled receptors may up-regulate the inflammatory response elicited
by ventilator-induced lung injury but also regulate cell survival via protein kinase B (Akt) and
extracellular signal regulated kinases 1/2 (ERK1/2). The G protein-sensitive
phosphoinositide-3-kinase γ (PI3Kγ) regulates several cellular functions including
inflammation and cell survival. We explored the role of PI3Kγ on ventilator-induced lung
injury. Design: Prospective, randomized, experimental study. Setting: University animal …
by ventilator-induced lung injury but also regulate cell survival via protein kinase B (Akt) and
extracellular signal regulated kinases 1/2 (ERK1/2). The G protein-sensitive
phosphoinositide-3-kinase γ (PI3Kγ) regulates several cellular functions including
inflammation and cell survival. We explored the role of PI3Kγ on ventilator-induced lung
injury. Design: Prospective, randomized, experimental study. Setting: University animal …