[HTML][HTML] ASB2 is an Elongin BC-interacting protein that can assemble with Cullin 5 and Rbx1 to reconstitute an E3 ubiquitin ligase complex
ML Heuzé, FC Guibal, CA Banks, JW Conaway… - Journal of Biological …, 2005 - ASBMB
The ankyrin repeat-containing protein with a suppressor of cytokine signaling box-2 (ASB2)
gene was identified as a retinoic acid-response gene and a target of the promyelocytic
leukemia-retinoic acid receptor-α oncogenic protein characteristic of acute promyelocytic
leukemia. Expression of ASB2 in myeloid leukemia cells inhibits growth and promotes
commitment, recapitulating an early step known to be critical for differentiation. Here we
show that ASB2, by interacting with the Elongin BC complex, can assemble with Cullin5 …
gene was identified as a retinoic acid-response gene and a target of the promyelocytic
leukemia-retinoic acid receptor-α oncogenic protein characteristic of acute promyelocytic
leukemia. Expression of ASB2 in myeloid leukemia cells inhibits growth and promotes
commitment, recapitulating an early step known to be critical for differentiation. Here we
show that ASB2, by interacting with the Elongin BC complex, can assemble with Cullin5 …
