[HTML][HTML] Th17 cells confer long-term adaptive immunity to oral mucosal Candida albicans infections
N Hernández-Santos, AR Huppler, AC Peterson… - Mucosal …, 2013 - Elsevier
Oropharyngeal candidiasis (OPC) is an opportunistic infection caused by Candida albicans.
Despite its prevalence, little is known about C. albicans-specific immunity in the oral
mucosa. Vaccines against Candida generate both T helper type 1 (Th1) and Th17
responses, and considerable evidence implicates interleukin (IL)-17 in immunity to OPC.
However, IL-17 is also produced by innate immune cells that are remarkably similar to Th17
cells, expressing the same markers and localizing to similar mucosal sites. To date, the …
Despite its prevalence, little is known about C. albicans-specific immunity in the oral
mucosa. Vaccines against Candida generate both T helper type 1 (Th1) and Th17
responses, and considerable evidence implicates interleukin (IL)-17 in immunity to OPC.
However, IL-17 is also produced by innate immune cells that are remarkably similar to Th17
cells, expressing the same markers and localizing to similar mucosal sites. To date, the …
