2-methoxyestradiol attenuates bleomycin-induced pulmonary hypertension and fibrosis in estrogen-deficient rats
SP Tofovic, X Zhang, EK Jackson, H Zhu… - Vascular …, 2009 - Elsevier
Pulmonary hypertension (PH) is a common and life-threatening complication of pulmonary
fibrosis. Estradiol (E2) is protective in experimental PH, and its non-estrogenic metabolite 2-
methoxyestradiol (2ME) prevents the development and retards the progression of
monocrotaline-induced PH in male and female rats. However, the effects of E2 and 2ME on
pulmonary fibrosis and associated PH have not been examined. Therefore, we compared
the growth inhibitory effects of E2 and 2ME in human lung fibroblasts (hLFs) and pulmonary …
fibrosis. Estradiol (E2) is protective in experimental PH, and its non-estrogenic metabolite 2-
methoxyestradiol (2ME) prevents the development and retards the progression of
monocrotaline-induced PH in male and female rats. However, the effects of E2 and 2ME on
pulmonary fibrosis and associated PH have not been examined. Therefore, we compared
the growth inhibitory effects of E2 and 2ME in human lung fibroblasts (hLFs) and pulmonary …