Sildenafil improves walk distance in idiopathic pulmonary fibrosis
HR Collard, KJ Anstrom, MI Schwarz, DA Zisman - Chest, 2007 - Elsevier
Pulmonary hypertension is a common finding in patients with idiopathic pulmonary fibrosis
(IPF), and is associated with increased morbidity and mortality. Therapy with sildenafil has
been shown to decrease pulmonary vascular resistance in patients with pulmonary fibrosis
and may improve functional status. Patients with IPF and documented pulmonary
hypertension were followed up in an open-label study of sildenafil. The 6-min walk test
distance (6MWD) was obtained before and after 3 months of sildenafil therapy. Fourteen …
(IPF), and is associated with increased morbidity and mortality. Therapy with sildenafil has
been shown to decrease pulmonary vascular resistance in patients with pulmonary fibrosis
and may improve functional status. Patients with IPF and documented pulmonary
hypertension were followed up in an open-label study of sildenafil. The 6-min walk test
distance (6MWD) was obtained before and after 3 months of sildenafil therapy. Fourteen …