Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

CC Goodnow, J Crosbie, S Adelstein, TB Lavoie… - Nature, 1988 - nature.com
CC Goodnow, J Crosbie, S Adelstein, TB Lavoie, SJ Smith-Gill, RA Brink
Nature, 1988nature.com
Immunological tolerance has been demonstrated in double-transgenic mice expressing the
genes for a neo-self antigen, hen egg lysozyme, and a high affinity anti-lysozyme antibody.
The majority of anti-lysozyme B-cells did not undergo clonal deletion, but were no longer
able to secrete anti-lysozyme antibody and displayed markedly reduced levels of surface
IgM while continuing to express high levels of surface IgD. These findings indicate that self
tolerance may result from mechanisms other than clonal deletion, and are consistent with …
Abstract
Immunological tolerance has been demonstrated in double-transgenic mice expressing the genes for a neo-self antigen, hen egg lysozyme, and a high affinity anti-lysozyme antibody. The majority of anti-lysozyme B-cells did not undergo clonal deletion, but were no longer able to secrete anti-lysozyme antibody and displayed markedly reduced levels of surface IgM while continuing to express high levels of surface IgD. These findings indicate that self tolerance may result from mechanisms other than clonal deletion, and are consistent with the hypothesis that IgD may have a unique role in B-cell tolerance.
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