Quantitative and functional impairment of pulmonary CD4+ CD25hi regulatory T cells in pediatric asthma
D Hartl, B Koller, AT Mehlhorn, D Reinhardt… - Journal of Allergy and …, 2007 - Elsevier
BACKGROUND: Asthma is characterized by a TH2 immune response. CD4+ CD25hi
regulatory T cells (Tregs) have been proposed to prevent allergic diseases through
suppression of TH2 responses. OBJECTIVE: We sought to investigate the role of CD4+
CD25hi T cells in children with asthma. METHODS: CD4+ CD25hi Tregs and
forkhead/winged-helix transcription factor FOXP3 mRNA levels were quantified in peripheral
blood and bronchoalveolar lavage fluid (BALF) of 18 children with asthma, 10 children with …
regulatory T cells (Tregs) have been proposed to prevent allergic diseases through
suppression of TH2 responses. OBJECTIVE: We sought to investigate the role of CD4+
CD25hi T cells in children with asthma. METHODS: CD4+ CD25hi Tregs and
forkhead/winged-helix transcription factor FOXP3 mRNA levels were quantified in peripheral
blood and bronchoalveolar lavage fluid (BALF) of 18 children with asthma, 10 children with …