Liver transplantation is accepted as the most reliable therapeutic option for patients with end-
stage liver failure, but lifelong administration of immunosuppressive agents continues to be
problematic due to various drug-induced morbidities and the risk of mortality. Complete
cessation of immunosuppressive drugs while maintaining normal graft function and
histology, called operational tolerance, has the potential to overcome these long-standing
problems. Previously, we reported the results of a pilot study of anti-donor regulatory T cell …