[HTML][HTML] Inactivation of ceramide synthase 6 in mice results in an altered sphingolipid metabolism and behavioral abnormalities
P Ebel, K Vom Dorp, E Petrasch-Parwez… - Journal of Biological …, 2013 - ASBMB
The N-acyl chain length of ceramides is determined by the specificity of different ceramide
synthases (CerS). The CerS family in mammals consists of six members with different
substrate specificities and expression patterns. We have generated and characterized a
mouse line harboring an enzymatically inactive ceramide synthase 6 (CerS6KO) gene and
lacz reporter cDNA coding for β-galactosidase directed by the CerS6 promoter. These mice
display a decrease in C16: 0 containing sphingolipids. Relative to wild type tissues the …
synthases (CerS). The CerS family in mammals consists of six members with different
substrate specificities and expression patterns. We have generated and characterized a
mouse line harboring an enzymatically inactive ceramide synthase 6 (CerS6KO) gene and
lacz reporter cDNA coding for β-galactosidase directed by the CerS6 promoter. These mice
display a decrease in C16: 0 containing sphingolipids. Relative to wild type tissues the …