C6-ceramide enhances Interleukin-12-mediated T helper type 1 cell responses through a cyclooxygenase-2-dependent pathway
CS Kue, MY Jung, D Cho, TS Kim - Immunobiology, 2012 - Elsevier
Ceramides, lipid molecules located predominantly within the plasma membrane of a cell,
can function as second messengers, and have been known to carry out a number of cellular
functions. T helper type 1 (Th1) immune responses are known to be involved in the cellular
immunity, which is crucial in the cancer and allergy immunotherapy. This study was
designed to evaluate the effects of ceramides on T helper cell responses and their
underlying mechanisms. We demonstrated that a cell-permeable C6-ceramide (C6) together …
can function as second messengers, and have been known to carry out a number of cellular
functions. T helper type 1 (Th1) immune responses are known to be involved in the cellular
immunity, which is crucial in the cancer and allergy immunotherapy. This study was
designed to evaluate the effects of ceramides on T helper cell responses and their
underlying mechanisms. We demonstrated that a cell-permeable C6-ceramide (C6) together …