Allergen-specific immunotherapy (AIT) has been used for more than 100 years as a
desensitizing therapy for IgE-mediated allergic diseases and represents a potentially
curative way of treatment. The mechanisms of action of AIT include the induction of very
early desensitization of mast cells and basophils; generation of regulatory T and regulatory
B (Breg) cell responses; regulation of IgE and IgG 4; decreases in numbers and activity of
eosinophils and mast cells in mucosal allergic tissues; and decreases in the activity of …