[HTML][HTML] Metabolic switch and hypertrophy of cardiomyocytes following treatment with angiotensin II are prevented by AMP-activated protein kinase
BJ Stuck, M Lenski, M Böhm, U Laufs - Journal of biological chemistry, 2008 - ASBMB
Angiotensin II induces cardiomyocyte hypertrophy, but its consequences on cardiomyocyte
metabolism and energy supply are not completely understood. Here we investigate the
effect of angiotensin II on glucose and fatty acid utilization and the modifying role of AMP-
activated protein kinase (AMPK), a key regulator of metabolism and proliferation. Treatment
of H9C2 cardiomyocytes with angiotensin II (Ang II, 1 μm, 4 h) increased [3 H] leucine
incorporation, up-regulated the mRNA expression of the hypertrophy marker genes MLC …
metabolism and energy supply are not completely understood. Here we investigate the
effect of angiotensin II on glucose and fatty acid utilization and the modifying role of AMP-
activated protein kinase (AMPK), a key regulator of metabolism and proliferation. Treatment
of H9C2 cardiomyocytes with angiotensin II (Ang II, 1 μm, 4 h) increased [3 H] leucine
incorporation, up-regulated the mRNA expression of the hypertrophy marker genes MLC …