Halofuginone treatment reduces interleukin-17A and ameliorates features of chronic lung allograft dysfunction in a mouse orthotopic lung transplant model
Background Increasing evidence suggests that interleukin (IL)-17A plays an important role
in chronic lung allograft dysfunction (CLAD), characterized by airway and lung parenchymal
fibrosis, after lung transplantation. Halofuginone is a plant derivative that has been shown to
inhibit Th17 differentiation. The purpose of this study was to examine the effect of
halofuginone on CLAD development using a minor alloantigen‒mismatched mouse
orthotopic lung transplant model. Methods C57BL/6 recipient mice received an orthotopic …
in chronic lung allograft dysfunction (CLAD), characterized by airway and lung parenchymal
fibrosis, after lung transplantation. Halofuginone is a plant derivative that has been shown to
inhibit Th17 differentiation. The purpose of this study was to examine the effect of
halofuginone on CLAD development using a minor alloantigen‒mismatched mouse
orthotopic lung transplant model. Methods C57BL/6 recipient mice received an orthotopic …